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Caveolins and Caveolae : Roles in Signaling and Disease Mechanisms

By: Jean-Francois Jasmin Philippe Frank Michael P. Lisanti (Author)

Ksh 23,310.00
Format :

Format(s): DRM PDF

ISBN-13: 9781461412229

Publisher: Springer New York

Imprint: Springer

Publication Date: March 12th, 2012

Country of Publication: US

Language: English

Physical Edition EAN: 9781461412212

Category: Medical research , Cytology

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  • Description

  • Author Bio

Caveolae are 50-100 nm flask-shaped invaginations of the plasma membrane that are primarily composed of cholesterol and sphingolipids. Using modern electron microscopy techniques, caveolae can be observed as omega-shaped invaginations of the plasma membrane, fully-invaginated caveolae, grape-like clusters of interconnected caveolae (caveosome), or as transcellular channels as a consequence of the fusion of individual caveolae. The caveolin gene family consists of three distinct members, namely Cav-1, Cav-2 and Cav-3. Cav-1 and Cav-2 proteins are usually co-expressed and particularly abundant in epithelial, endothelial, and smooth muscle cells as well as adipocytes and fibroblasts. On the other hand, the Cav-3 protein appears to be muscle-specific and is therefore only expressed in smooth, skeletal and cardiac muscles. Caveolin proteins form high molecular weight homo- and/or hetero-oligomers and assume an unusual topology with both their N- and C-terminal domains facing the cytoplasm.

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