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Evolution of Translational Omics : Lessons Learned and the Path Forward

By: Institute of Medicine Board on Health Sciences Policy Board on Health Care Services Committee on the Review of Omics-Based Tests for Predicting Patient Outcomes in Clinical Trials Gilbert S. Omenn Sharly J. Nass Christine M. Micheel (Author)

Ksh 540.00
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Format(s): DRM PDF

ISBN-13: 9780309224192

Publisher: National Academies Press

Imprint: National Academies Press

Publication Date: August 13th, 2012

Country of Publication: US

Language: English

Pages: 354

Physical Edition EAN: 9780309224185

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  • Description

  • Author Bio

Technologies collectively called omics enable simultaneous measurement of an enormous number of biomolecules; for example, genomics investigates thousands of DNA sequences, and proteomics examines large numbers of proteins. Scientists are using these technologies to develop innovative tests to detect disease and to predict a patient's likelihood of responding to specific drugs. Following a recent case involving premature use of omics-based tests in cancer clinical trials at Duke University, the NCI requested that the IOM establish a committee to recommend ways to strengthen omics-based test development and evaluation. This report identifies best practices to enhance development, evaluation, and translation of omics-based tests while simultaneously reinforcing steps to ensure that these tests are appropriately assessed for scientific validity before they are used to guide patient treatment in clinical trials.

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