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Gene and Cell Delivery for Intervertebral Disc Degeneration

By: Raquel Madeira Goncalves Mario Adolfo Barbosa (Author)

Ksh 7,290.00
Format :

Format(s): DRM PDF

ISBN-13: 9781351030175

Publisher: CRC Press

Imprint: CRC Press

Publication Date: April 27th, 2018

Language: English

Pages: 259

Physical Edition EAN: 9781498799409

Category: Cytology , Rheumatology , Orthopaedics & fractures , Rehabilitation: brain & spinal injuries , Cellular biology (cytology)

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  • Author Bio

Intervertebral disc degeneration is one of the major causes of lower back pain for which the common therapeutic interventions are not efficient. A search for alternative therapies for lower back pain and intervertebral disc degeneration includes cell-based therapies. Unfortunately, intervertebral disc degeneration is avascular and thus a hostile environment for cell survival. Furthermore, cellular characterization in intervertebral disc degeneration, and particularly in the nucleus pulposus, is controversial, mainly due to lack of specific markers and species variability. This book adds to the knowledge on cellular and molecular therapies for intervertebral disc degeneration and associated lower back pain. Key Selling Features:Describes the ontogeny and phenotype of intervertebral disc cellsReviews the role that inflammation plays in disco-genic painHighlights the types of cells that might be used as sources for treating degenerating intervertebral discsSummarizes current alternative therapiesExplores methods for cell delivery into degenerated intervertebral discs

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